During his PhD, he developed synthetic biology Massively Parallel Reporter Assay (MPRA) and statistical and thermodynamic models, which he applied to decipher the encoding of transcriptional regulation in yeast. DasGupta R*, Kaykas A*, Moon RT, Perrimon N. Science. This work transformed all stages of drug discovery at Cytokinetics and made the company one of the leaders in high content assays and screening. She was named a MacArthur Fellow in 2004, was elected a member of the National Academy of Engineering in 2011 and was elected a fellow of the American Academy of Arts and Sciences in 2014. Prior to Biogen, Rachel worked at Pfizer’s Centers for Therapeutic Innovation. She brings with her 18 years of experience in accounting and finance operations with most of her experience in the life sciences industry. Modern medicine has given us effective tools to treat some of the most significant and burdensome diseases. Perry completed his Ph.D. in the Bioinformatics and Integrative Genomics program at Harvard Medical School where his research focused on using statistical models to predict protein structure from sequence variation. Ihry RJ, Worringer KA, Salick MR, Frias E, Ho D, Theriault K, Kommineni S, Chen J, Sondey M, Ye C, Randhawa R, Kulkarni T, Yang Z, McAllister G, Russ C, Reece-Hoyes J, Forrester W, Hoffman GR, Dolmetsch R, Kaykas A. Nat Med. As the Director of Neuroscience, Rachel leads insitro’s therapeutic strategy in neuroscience-related indications in collaboration with her talented colleagues. *Co-first authors. Ellie helped the Company prepare for IPO in 2015 and built the team to scale as a public company. On the other hand, bioengineering and cell biology have advanced enough to produce vast amounts of data that can be analyzed by AI and machine learning algorithms. In her time at Aimmune, she raised more than $650 million in capital through a range of private and public transactions including leadership of the company’s 2015 IPO. Yao Z, Mich JK, Ku S, Menon V, Krostag AR, Martinez RA, Furchtgott L, Mulholland H, Bort S, Fuqua MA, Gregor BW, Hodge RD, Jayabalu A, May RC, Melton S, Nelson AM, Ngo NK, Shapovalova NV, Shehata SI, Smith MW, Tait LJ, Thompson CL, Thomsen ER, Ye C, Glass IA, Kaykas A, Yao S, Phillips JW, Grimley JS, Levi BP, Wang Y, Ramanathan S. Cell Stem Cell. Before then, Britt was the VP of People at Kiva, the world’s first personal micro-lending platform, where she supported the organization’s doubling in size, internationalization, and creation of an awesome culture. in Systems Engineering from Penn State University. A Single-Cell Roadmap of Lineage Bifurcation in Human ESC Models of Embryonic Brain Development. 2018 Dec 11;115(50):E11701-E11710. Fast Company’s Ruth Reader interviewed Daphne Koller on how Insitro, her startup, was making a difference in drug discovery and development. In his spare time, he and his family enjoy cooking together, traveling and exploring the world’s ecology under the sea (marvelling at Ostracod mating practices in the Carribean), in jungles (visits to the Sarawak Biodiversity Centre in Borneo), and in ecology parks (riding dolphins in Tunisia). Britt holds an MBA from St. Mary’s College, Moraga, California and a Senior Professional in Human Resources (SPHR)-Certification. Patin E, Hasan M, Bergstedt J, Rouilly V, Libri V, Urrutia A, Alanio C, Scepanovic P, Hammer C, Jönsson F, Beitz B, Quach H, Lim YW, Hunkapiller J, Zepeda M, Green C, Piasecka B, Leloup C, Rogge L, Huetz F, Peguillet I, Lantz O, Fontes M, Di Santo JP, Thomas S, Fellay J, Duffy D, Quintana-Murci L, Albert ML; Milieu Intérieur Consortium. Prior to joining insitro, Britt served as VP, People & Organizational Development at PaxVax, Inc., a fully-integrated specialty vaccines company, which she helped build and scale from start-up to a global, commercial stage company that was acquired by Emergent BioSolutions in 2018. WSAI Americas 2019 - insitro, Daphne Koller, Founder and CEO - Duration: 24:37. Support this podcast by signing up with these sponsors: – … The two companies will integrate a mining site and…, © 2020 DailyAlts. Current investors including ARCH Venture Partners, GV, and Third Rock Ventures also invested. 2015 Oct 16;350(6258):328-34. doi: 10.1126/science.aad0395. Big data, machine learning and biology are suddenly in syzygy and Koller is intent on making the most of it with her new company, Insitro — and telling us all about it at Disrupt SF 2020. During his graduate training with Dr. Howard Chang at Stanford University, Chu invented an RNA-interactome analysis method, “ChIRP,” to study the mechanism of X-chromosome inactivation by the famous long noncoding RNA “Xist”, among many other projects, via genomics, imaging and protein mass spec assays. Eilon has extensive experience in applying machine learning to decipher various biological questions. Perry is the Director of Strategy and Corporate Development at insitro. jQuery(document).ready(function($){gformInitSpinner( 3, 'https://dailyalts.com/wp-content/plugins/gravityforms/images/spinner.gif' );jQuery('#gform_ajax_frame_3').on('load',function(){var contents = jQuery(this).contents().find('*').html();var is_postback = contents.indexOf('GF_AJAX_POSTBACK') >= 0;if(!is_postback){return;}var form_content = jQuery(this).contents().find('#gform_wrapper_3');var is_confirmation = jQuery(this).contents().find('#gform_confirmation_wrapper_3').length > 0;var is_redirect = contents.indexOf('gformRedirect(){') >= 0;var is_form = form_content.length > 0 && ! In Press, Sept; 2018 Nat. Prior to joining insitro, Matthew worked as Principal Scientist in the Department of Cancer Immunology at Genentech (2015 – 2019); and served as Professor (2003 – 2015), Founder and Director of the Center for Human Immunology (2007 – 2015) and Director of the Immunology Department at Institut Pasteur, Paris France (2010 – 2015). But after stumbling into biology a few years later because of the novelty of the small but diverse data sets it offered, the field quickly drew her in. Prior to joining insitro, Adriana was a Principal at The Column Group (TCG), a life science venture capital firm. Koller said Insitro was looking at the various vaccine approaches from different companies and “putting them in with a bunch of viral protein and hoping for the best,” – because techniques do not currently exist to predict vaccine efficacy. Co-founder, Coursera. Share. He then earned a PhD from the Weizmann Institute of Science under the supervision of Prof. Eran Segal. Eugeni Vaisberg, Ph.D., is Vice President, Disease Model Systems and Arrayed Screening at insitro. He received his Ph.D. in Biochemistry from the Institute of Protein Research, USSR Academy of Sciences, Moscow, USSR. Before joining insitro, Keith was President of the Ferring Research Institute in San Diego, engaged in the discovery of peptide therapeutics. is_confirmation;var mt = parseInt(jQuery('html').css('margin-top'), 10) + parseInt(jQuery('body').css('margin-top'), 10) + 100;if(is_form){jQuery('#gform_wrapper_3').html(form_content.html());if(form_content.hasClass('gform_validation_error')){jQuery('#gform_wrapper_3').addClass('gform_validation_error');} else {jQuery('#gform_wrapper_3').removeClass('gform_validation_error');}setTimeout( function() { /* delay the scroll by 50 milliseconds to fix a bug in chrome */ jQuery(document).scrollTop(jQuery('#gform_wrapper_3').offset().top - mt); }, 50 );if(window['gformInitDatepicker']) {gformInitDatepicker();}if(window['gformInitPriceFields']) {gformInitPriceFields();}var current_page = jQuery('#gform_source_page_number_3').val();gformInitSpinner( 3, 'https://dailyalts.com/wp-content/plugins/gravityforms/images/spinner.gif' );jQuery(document).trigger('gform_page_loaded', [3, current_page]);window['gf_submitting_3'] = false;}else if(!is_redirect){var confirmation_content = jQuery(this).contents().find('.GF_AJAX_POSTBACK').html();if(!confirmation_content){confirmation_content = contents;}setTimeout(function(){jQuery('#gform_wrapper_3').replaceWith(confirmation_content);jQuery(document).scrollTop(jQuery('#gf_3').offset().top - mt);jQuery(document).trigger('gform_confirmation_loaded', [3]);window['gf_submitting_3'] = false;}, 50);}else{jQuery('#gform_3').append(contents);if(window['gformRedirect']) {gformRedirect();}}jQuery(document).trigger('gform_post_render', [3, current_page]);} );} ); jQuery(document).bind('gform_post_render', function(event, formId, currentPage){if(formId == 3) {if(typeof Placeholders != 'undefined'){ He earned his PhD in Oncology from The Johns Hopkins University School of Medicine. She was the co-founder, co-CEO and President of Coursera for 5 years, and the Chief Computing Officer of Calico, an Alphabet company in the healthcare space. Prior to Amgen Eugeni served as Director of Lead Discovery at iPierian where he was responsible for building one of the world’s first “disease in a dish” drug discovery platforms based on cellular reprogramming technology, advanced high throughput screens, and data analysis. He majored in physics at Princeton University where his senior thesis focused on modeling viral gene regulatory circuits. Proc Natl Acad Sci U S A. the life sciences and technology industries, both in California and in Switzerland. Big data, machine learning and biology are suddenly in syzygy and Koller is intent on making the most of it with her new company, Insitro — and telling us all about it at Disrupt SF 2020. During his time in Oncology, Jason helped lead the team that discovered and developed Encorafenib, approved as BRAFTOVI for the treatment of B-Raf mutant melanoma. in Biology and Neuroscience from Macalester College. New investors who participated included T. Rowe Price Associate, BlackRock, Casdin Capital, and CPP Investments. Ellie also spent time at Ironwood Pharmaceuticals during phase III clinical trials of Linaclotide (FDA approval 2012). Before that, he served as associate general counsel in charge of patent development at Yahoo! He is the author of more than 100 peer-reviewed scientific papers and has made major contributions to the understanding of antigen cross-priming and the impact of post-translational modification of chemokines as determinants of effective tumor immunity. Subscribe to our free newsletter for updates and news about alternatives investments. Before joining iPierian Eugeni worked at Cytokinetics where he was one of the founding scientists and held multiple positions of increasing responsibility. Before then, Allison was at Genomic Health, a global provider of genomic-based diagnostic tests, where she was most recently the Senior Director of Accounting and supported the organization’s increasing headcount and international growth. After completing a dual major B.Sc. This former Stanford University professor’s cutting edge work combines machine learning and biology to transform pharmaceutical drug development. She speaks English, German, French, Italian, and Spanish. Ye C, Ho DJ, Neri M, Yang C, Kulkarni T, Randhawa R, Henault M, Mostacci N, Farmer P, Renner S, Ihry R, Mansur L, Gubser Keller C, McAllister G, Hild M, Jenkins J, and Kaykas A. As Director of Data Science, Eilon is leading the development of cutting edge machine learning, computational biology and statistical genetics approaches to improve drug development. 2018 Jul;24(7):939-946. Daphne Koller is the CEO and Founder of insitro. Before joining insitro, Aj led the early target discovery team at Novartis Institutes for Biomedical Research in the Neuroscience unit. Airbnb listed…, Valour, a Swiss firm that creates innovative financial products, has launched Bitcoin Zero. Over his career, Duane has been named multiple times to the IAM Strategy 300, recognizing the world’s leading IP strategists. During his career, Keith, and the organizations he has led, have delivered over thirty clinical candidates, across fifteen therapeutic areas, many of which have reached Phase 2, and two of which are in the hands of physicians treating patients today – eletriptan (Relpax®) for migraines and maraviroc (Selzentry®) for HIV infections. In the News Forbes: A Star Professor—And Her Radical, AI-Powered Plan To Discover New Drugs. Forbes: insitro on the list of AI 50: America’s Most Promising Artificial Intelligence Companies Inc.: Our founder and CEO Daphne Koller has been selected as one of Inc.’s 100 Female Founders Previously, Adriana did research in the lab of Prof. Rudolf Jaenisch as an undergraduate at the Massachusetts Institute of Technology. In his free time, Duane enjoys cooking, traveling, live jazz, yoga, the outdoors and quality time with his family. His roles spanned portfolio strategy, program management, and scientific operations. 2016 Dec 1;19(6):703-708. Allison Lai is the Controller / VP, Finance at insitro. Insitro founder and CEO Daphne Koller (left) and CFO Mary Rozenman (right). Wells MF, Salick MR, Wiskow O, Ho DJ, Worringer KA, Ihry RJ, Kommineni S, Bilican B, Klim JR, Hill EJ, Kane LT, Ye C, Kaykas A*, Eggan K.* Cell Stem Cell. Prior to joining the insitro team, she served as the senior vice president of corporate development and strategy at Aimmune Therapeutics, leading business development and partnerships with companies such as Regeneron/Sanofi and Nestlé Health Science, and supporting the company’s strategic finance and investor relations efforts. Coursera and Insitro founder Daphne Koller is coming to Disrupt 2020. As Senior Vice-President of Drug Discovery, Keith is responsible for machine learning-enabled drug discovery programs at insitro. In his free time, Eilon enjoys hiking and camping outdoors with his family. At stanford, Eilon worked on a diverse set of projects including: detection and fine mapping of genetic associations with T cell receptor V-genes expression; software for transplant health monitoring using cell-free DNA sequencing (which was commercialized by Stanford); and detection of functional genetic variants using a novel high throughput CRISPR editing. 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