marianum Silybum pygmaeum Cass. Silybum maculatum (Scop.) Use of silymarin was associated with less fibrosis as measured by the Ishak fibrosis score, but this association was not noted for clinical outcome measures.Freedman 2011 The American Association for Study of Liver Disease (AASLD) practice guidelines for primary biliary cirrhosis (2009) and primary biliary cholangitis (2018) state that the addition of silymarin to ursodeoxycholic acid provided no additional benefit.Lindor 2009, Lindor 2019, A meta-analysis evaluated English and Chinese randomized placebo-controlled trials from 1966 to December 2011 to determine the safety and efficacy of silymarin as monotherapy and combination therapy for treatment of chronic hepatitis B.Wei 2013 Data from 12 trials (N=1,096) suggest silymarin is equivalent to antiviral or hepatoprotective drugs with regard to effects on serum transaminases, viral load, and hepatic fibrosis markers. “An erect annual or biennial herb, commonly 90 to 180 cm high. Proper name(s), Common name(s), Source material(s) Table 1. Silymarin was well tolerated.Luangchosiri 2015, In another similar study assessing the effects of silibinin on anti-TB drug–induced liver injury, different results were discovered. Liver iron concentration was also significantly reduced with administration of silymarin (P=0.02). Common Names. & Fourr. Select one or more newsletters to continue. Common names: blessed milkthistle, milk thistle, Marian thistle, Mary thistle, Saint Mary’s thistle, Mediterranean milk thistle, variegated thistle . Devon EX7 9LX England. Milk thistle (Silybum marianum L. Milk thistle has traditionally been used in pregnancy. Common names are from state and federal lists. turmeric, echinacea, saw palmetto, Ginkgo Biloba, garlic. Members of this genus grow as annual or biennial plants. In turn, patients can develop iron overload, leading to oxidative stress and organ damage.Moayedi Esfahani 2015 Milk thistle has been suggested to be an iron chelator and has been evaluated in thalassemia for its ability to mitigate these effects.Neha 2016, A small trial (N=30) investigated the humoral and cell-mediated immunomodulatory effects of silymarin (140 mg 3 times daily) added to desferrioxamine therapy (40 mg/kg/day) for 12 weeks in patients 12 years and older with beta-thalassemia; 5 patients who were unable or unwilling to take desferrioxamine therapy received silymarin monotherapy. Quick facts . The fruits make up the thistle portion along with its silvery pappus, which readily falls away and is not used for the extract preparation.Mastron 2015, Neha 2016, NIH 2018, USDA 2018, WHO 2004. Silybum marianum (L.) Gaertn. Variegated thistle is very competitive in pastures and, … Grow in average, moderately fertile, well-drained soils in full sun. Scientific Name: Silybum marianum (Syn. This information is not specific medical advice and does not replace information you receive from your health care provider. Carduus marianus L. Family. longispinum Lamotte, 1881 Silybum marianum var. Silymarin is composed of 65% to 80% of a complex of flavonolignans: silybin A, silybin B, isosilybin A, isosilybin B, silychristin, isosilychristin, silydianin, and the flavonoid taxifoline. However, fewer cases of nausea and anorexia were reported in patients receiving silibinin compared with those who were not, and more patients in the silibinin group had negative smear cultures compared with those who did not receive silibinin.Gu 2015, In a randomized controlled trial conducted in China (N=370), patients received anti-TB therapy with either supplemental S. marianum (200 mg twice daily) or vitamin C; no significant difference in the occurrence of probable or possible anti-TB drug–induced liver injury was observed between the 2 groups. Milk production was enhanced with no change to its chemical composition.Di Pierro 2008, There is mixed data regarding milk thistle's ability to exert inhibitory or inductive activity on CYP1A2, 2C19, 2D6, 2E1, and 3A4, as well as P-glycoprotein. Milk thistle has demonstrated efficacy in liver damage associated with acetaminophen, arsenic, and carbon tetrachloride.Neha 2016, In a study of rats, silibinin mitigated the increases in liver function measures caused by combination therapy with isoniazid and zidovudine.Ramanathan 2017, Prevention of anti-tuberculosis (TB) drug–induced liver injury was assessed in a double-blind, randomized, placebo-controlled trial in patients with newly diagnosed pulmonary tuberculosis (N=55) who planned to receive standard therapy with isoniazid, rifampicin, pyrazinamide, and ethambutol. Scientific Name: Silybum marianum Common name: Variegated thistle Page 1 of 2 QUESTION COMMENTS REFERENCE RANKING Social 1. These data indicate recovery of immune status and cytokine production.Gharagozloo 2013, The iron-chelating effects of silymarin were evaluated in a triple-blind, randomized, placebo-controlled crossover trial of patients with transfusion-dependent beta-thalassemia (N=82). Milk Thistle - Silybum marianum (L.) Gaertn. The large, alternate leaves are waxy-lobed, toothed and thorny, as in other genera of thistle. Treatment was well tolerated with no adverse events reported.Ebrahimpour-Koujan 2018. Latin Name: Silybum marianum Common Names: Milk Thistle Seeds. Pricing Help Me Choose. Silybum marianum is a plant that is used for centuries as a herbal treatment in liver and biliary tract diseases. According to legend, the variegation on the leaves was caused by the virgin Mary’s milk as it ran down the leaves, hence the specific name marianum. Common Name: Milk Thistle | Scientific Name: Silybum Marianum. Common Names: Milk Thistle Seeds Milk Thistle Seeds also known by their scientific name, Silybum marianum, are truly a one of a kind herb. Milk thistle is contraindicated in patients with allergy to any plant in the Asteraceae family. Silybum marianum (L.) Gaertn. Early colonists introduced milk thistle to North America. Silybum marianum (L.) Gaertn. Collection and disposal of spiny stems and leaves from plants that have died can be time-consuming. Chardon Marie. Daisy family (Asteraceae) Common name. The flowers consist of tubular florets. Use of milk thistle or its active components as adjunctive therapy to prevent chemotoxicities associated with chemotherapy and/or radiation has been studied. At 2, 4, and 8 weeks, there were no differences between the 2 groups in the incidence of liver injury. When broken, the leaves and stems exude a milky sap, from which the plant derives its name. Silybum marianum : Source: NODC Taxonomic Code, database (version 8.0) Acquired: 1996 : Notes: Reference for: Silybum marianum ... Common Name: Scientific Name : TSN: In: Kingdom Go to Advanced Search and Report . Silymarin gel (1%) containing 80% active ingredient based on silymarin flavonolignans was applied twice daily to the soles and palms for the 9-week chemotherapy cycle. A group of 277 patients receiving conventional TB therapy and also given silibinin 70 mg 3 times daily for 8 weeks was compared with 291 patients receiving only conventional therapy for TB. However, when silymarin was combined with these agents, serum indices and hepatic markers were reduced. 08 Sep 2020 Gaert., Asteraceae) seeds have been used for centuries as a herbal medicine, mainly for the treatment of liver diseases.The common name, milk thistle, is derived from the milky-white veins on the leaves, which, when broken open, yield a milky sap. Family: Asteraceae Part used: Fruit/Seed Constituents: Flavolignans (silymarin complex), flavonoids, volatile oil, bitter principle, mucilage Actions: Cholagogue, hepatic, hepatoprotective & hepatorestorative, galactagogue, demulcent Medical uses: Research has shown that it promotes the regeneration of diseased liver cells and protects them … Maximum ALT level within 4 weeks and development of anti-TB drug–induced liver injury were the primary and secondary outcome measures, respectively. The plant is easy recognized because of the white veins on the leaves, which gave it the name of milk thistle. Isolated. Milkthistle fruit is the common name for the fruit of the plant Silybum marianum (L.) Gaertn.. Watch for slugs and snails. Common Name: blessed milkthistle . The flowers are reddish-purple and ridged with sharp spines. Silybum marianum is sometimes known as Blessed Thistle. Monitor therapy.DiCenzo 2003, Jiao 2009, Mills 2005, Piscitelli 2002, In most clinical trials, the incidence of adverse reactions was approximately equal in milk thistle and control groups.Zhu 2018 The US Agency for Healthcare Research and Quality and the German Commission E reported no serious adverse events associated with milk thistle within the recommended dosage range.Post-White 2007, Rainone 2005, Silymarin is well tolerated; the most common effects after oral ingestion were brief GI disturbances (eg, abdominal bloating, abdominal fullness or pain, anorexia, changes in bowel habits, diarrhea, dyspepsia, flatulence, nausea). Silymarin is well tolerated; the most common adverse effects after oral ingestion were brief GI disturbances (eg, abdominal bloating, abdominal fullness or pain, anorexia, changes in bowel habits, diarrhea, dyspepsia, flatulence, nausea). Silybum marianum var. Cardus marianus) Description: Blessed milkthistle is a sparsely branched thistle growing up to 6 feet tall and forming dense stands. Silybin A and B, diastereoisomers of silibinin in a 1:1 ratio, are considered the most biologically active components. Flowers are crimson to reddish … That's the trouble with common names - they can be applied to more than one plant. NVS maintains a standard set of species code abbreviations that correspond to standard scientific plant names from the Ngä Tipu o Aotearoa - New Zealand Plants database. Scientific name: Carduus marianus (L.) Common name: Holy thistle, milk thistle, Our Lady's thistle: Hebrew name: גדילן מצוי: Arabic name: خرفيش جمال: Egypt: شوك الجمل "Shouk El-Gamal" Plant Family: Compositae / Asteraceae, מורכבים File Size. For growth as a biennial, sow seed directly in the garden from May to August (flowers will not appear until the second year). She recalled taking milk thistle for headaches and liver cleansing for about 2 months. Invasive Species: Silybum marianum, Blessed Milkthistle. Synonym. Click on a place name to get a complete noxious weed list for that location, or click here for a ... (Silybum marianum) (SIMA3) Herbal Information Resources (SIMA3) New Zealand Environment Bay of Plenty: abstract & images (SIMA3) Although the sample size was relatively small, administration of silymarin significantly reduced the incidence of anti-TB drug–induced liver injury at week 4 compared with placebo (3.7% vs 32.1%, respectively; P=0.012). Preferred Scientific Name; Silybum marianum Preferred Common Name; variegated thistle Taxonomic Tree; Domain: Eukaryota Kingdom: Plantae Phylum: Spermatophyta Subphylum: Angiospermae Class: Dicotyledonae; Summary of Invasiveness ; S. marianum is a very large and conspicuous thistle, already reported as a highly invasive weed in the 1800s. Plants range from 2-6 ft. (0.6-1.8 m) in height, depending on soil moisture. We comply with the HONcode standard for trustworthy health information -, https://nccih.nih.gov/health/milkthistle/ataglance.htm, https://clinicaltrials.gov/ct2/results?cond=&term=milk+thistle&cntry=&state=&city=&dist=. Caution should be used when coadministering iron/copper-containing supplements with milk thistle.Tvrdý 2018, Raloxifene: Coadministration of milk thistle and raloxifene may lead to 4- to 5-fold increases in raloxifene systemic exposure due to inhibition of intestinal glucuronidation by silybin A and silybin B. Milk Thistle is unique in its ability to protect the liver and has no equivalent in the pharmaceutical drug world. The erect stem is tall, branched and furrowed but not spiny. The HMPC conclusions only cover milkthistle fruit preparations that are obtained by drying and comminuting (reducing into tiny pieces) or powdering the fruit or putting the plant material in a solvent (acetone, ethanol, ethyl acetate or methanol) to dissolve compounds and form a liquid extract. Scientific Name(s): Silybum marianum (L.) Gaertn.Common Name(s): Carduus marianus, Fructus cardui mariae, Fructus silybi mariae, Mariana mariana, Blessed milk thistle, Bull thistle, Chardon de Marie, Holy thistle, Lady's milk, Lady's thistle, Marian thistle, Mary thistle, Mild marian thistle, Milk thistle, Pternix, Shui fei ji, Silberdistil, Silibinin, Silybe, Silybon, Silybum, Silymarin, St. Mary's thistle, Thistle, Thistle of the Blessed Virgin, Wild artichoke. Thats a bit hint as to what this plant does…..it protects the liver from damage. Moench Silybum mariae (Cr.) Flowering plants may spread by self-seeding unless flowers are promptly deadheaded after bloom. 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